Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis.
Identifieur interne : 000A55 ( Main/Exploration ); précédent : 000A54; suivant : 000A56Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis.
Auteurs : Kathryn M. Rowan [Royaume-Uni] ; Derek C. Angus [États-Unis] ; Michael Bailey [Australie] ; Amber E. Barnato [États-Unis] ; Rinaldo Bellomo [Australie] ; Ruth R. Canter [Royaume-Uni] ; Timothy J. Coats [Royaume-Uni] ; Anthony Delaney [Australie] ; Elizabeth Gimbel [États-Unis] ; Richard D. Grieve [Royaume-Uni] ; David A. Harrison [Royaume-Uni] ; Alisa M. Higgins [Australie] ; Belinda Howe [Australie] ; David T. Huang [États-Unis] ; John A. Kellum [États-Unis] ; Paul R. Mouncey [Royaume-Uni] ; Edvin Music [États-Unis] ; Sandra L. Peake [Australie] ; Francis Pike ; Michael C. Reade [Australie] ; M Zia Sadique [Royaume-Uni] ; Mervyn Singer [Royaume-Uni] ; Donald M. Yealy [États-Unis]Source :
- The New England journal of medicine [ 1533-4406 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Analyse coût-bénéfice (MeSH), Analyse de survie (MeSH), Années de vie ajustées sur la qualité (MeSH), Association thérapeutique (MeSH), Cardiotoniques (usage thérapeutique), Choc septique (mortalité), Choc septique (thérapie), Essais contrôlés randomisés comme sujet (MeSH), Femelle (MeSH), Guides de bonnes pratiques cliniques comme sujet (MeSH), Hospitalisation (économie), Humains (MeSH), Mortalité hospitalière (MeSH), Mâle (MeSH), Perfusions veineuses (MeSH), Réanimation (méthodes), Réanimation (économie), Résultat thérapeutique (MeSH), Sujet âgé (MeSH), Traitement par apport liquidien (MeSH), Transfusion d'érythrocytes (MeSH), Vasoconstricteurs (usage thérapeutique).
- MESH :
- mortalité : Choc septique.
- méthodes : Réanimation.
- thérapie : Choc septique.
- usage thérapeutique : Cardiotoniques, Vasoconstricteurs.
- économie : Hospitalisation, Réanimation.
- Adulte d'âge moyen, Analyse coût-bénéfice, Analyse de survie, Années de vie ajustées sur la qualité, Association thérapeutique, Essais contrôlés randomisés comme sujet, Femelle, Guides de bonnes pratiques cliniques comme sujet, Humains, Mortalité hospitalière, Mâle, Perfusions veineuses, Résultat thérapeutique, Sujet âgé, Traitement par apport liquidien, Transfusion d'érythrocytes.
English descriptors
- KwdEn :
- Aged (MeSH), Cardiotonic Agents (therapeutic use), Combined Modality Therapy (MeSH), Cost-Benefit Analysis (MeSH), Erythrocyte Transfusion (MeSH), Female (MeSH), Fluid Therapy (MeSH), Hospital Mortality (MeSH), Hospitalization (economics), Humans (MeSH), Infusions, Intravenous (MeSH), Male (MeSH), Middle Aged (MeSH), Practice Guidelines as Topic (MeSH), Quality-Adjusted Life Years (MeSH), Randomized Controlled Trials as Topic (MeSH), Resuscitation (economics), Resuscitation (methods), Shock, Septic (mortality), Shock, Septic (therapy), Survival Analysis (MeSH), Treatment Outcome (MeSH), Vasoconstrictor Agents (therapeutic use).
- MESH :
- chemical , therapeutic use : Cardiotonic Agents, Vasoconstrictor Agents.
- economics : Hospitalization, Resuscitation.
- methods : Resuscitation.
- mortality : Shock, Septic.
- therapy : Shock, Septic.
- Aged, Combined Modality Therapy, Cost-Benefit Analysis, Erythrocyte Transfusion, Female, Fluid Therapy, Hospital Mortality, Humans, Infusions, Intravenous, Male, Middle Aged, Practice Guidelines as Topic, Quality-Adjusted Life Years, Randomized Controlled Trials as Topic, Survival Analysis, Treatment Outcome.
Abstract
BACKGROUND
After a single-center trial and observational studies suggesting that early, goal-directed therapy (EGDT) reduced mortality from septic shock, three multicenter trials (ProCESS, ARISE, and ProMISe) showed no benefit. This meta-analysis of individual patient data from the three recent trials was designed prospectively to improve statistical power and explore heterogeneity of treatment effect of EGDT.
METHODS
We harmonized entry criteria, intervention protocols, outcomes, resource-use measures, and data collection across the trials and specified all analyses before unblinding. After completion of the trials, we pooled data, excluding the protocol-based standard-therapy group from the ProCESS trial, and resolved residual differences. The primary outcome was 90-day mortality. Secondary outcomes included 1-year survival, organ support, and hospitalization costs. We tested for treatment-by-subgroup interactions for 16 patient characteristics and 6 care-delivery characteristics.
RESULTS
We studied 3723 patients at 138 hospitals in seven countries. Mortality at 90 days was similar for EGDT (462 of 1852 patients [24.9%]) and usual care (475 of 1871 patients [25.4%]); the adjusted odds ratio was 0.97 (95% confidence interval, 0.82 to 1.14; P=0.68). EGDT was associated with greater mean (±SD) use of intensive care (5.3±7.1 vs. 4.9±7.0 days, P=0.04) and cardiovascular support (1.9±3.7 vs. 1.6±2.9 days, P=0.01) than was usual care; other outcomes did not differ significantly, although average costs were higher with EGDT. Subgroup analyses showed no benefit from EGDT for patients with worse shock (higher serum lactate level, combined hypotension and hyperlactatemia, or higher predicted risk of death) or for hospitals with a lower propensity to use vasopressors or fluids during usual resuscitation.
CONCLUSIONS
In this meta-analysis of individual patient data, EGDT did not result in better outcomes than usual care and was associated with higher hospitalization costs across a broad range of patient and hospital characteristics. (Funded by the National Institute of General Medical Sciences and others; PRISM ClinicalTrials.gov number, NCT02030158 .).
DOI: 10.1056/NEJMoa1701380
PubMed: 28320242
Affiliations:
- Australie, Royaume-Uni, États-Unis
- Angleterre, Grand Londres, Nouvelle-Galles du Sud, Pennsylvanie
- Londres, Pittsburgh, Sydney
- University College de Londres, Université de Sydney
Links toward previous steps (curation, corpus...)
Le document en format XML
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Reade</name><affiliation wicri:level="1"><nlm:affiliation>University of Queensland, Brisbane, Australia</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Sadique, M Zia" sort="Sadique, M Zia" uniqKey="Sadique M" first="M Zia" last="Sadique">M Zia Sadique</name><affiliation wicri:level="3"><nlm:affiliation>London School of Hygiene and Tropical Medicine, London, United Kingdom</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Singer, Mervyn" sort="Singer, Mervyn" uniqKey="Singer M" first="Mervyn" last="Singer">Mervyn Singer</name><affiliation wicri:level="4"><nlm:affiliation>University College London, London, United Kingdom</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Yealy, Donald M" sort="Yealy, Donald M" uniqKey="Yealy D" first="Donald M" last="Yealy">Donald M. Yealy</name><affiliation wicri:level="3"><nlm:affiliation>University of Pittsburgh School of Medicine, Pittsburgh</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><wicri:orgArea>University of Pittsburgh School of Medicine</wicri:orgArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28320242</idno><idno type="pmid">28320242</idno><idno type="doi">10.1056/NEJMoa1701380</idno><idno type="wicri:Area/Main/Corpus">000A08</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000A08</idno><idno type="wicri:Area/Main/Curation">000A08</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000A08</idno><idno type="wicri:Area/Main/Exploration">000A08</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis.</title><author><name sortKey="Rowan, Kathryn M" sort="Rowan, Kathryn M" uniqKey="Rowan K" first="Kathryn M" last="Rowan">Kathryn M. Rowan</name><affiliation wicri:level="3"><nlm:affiliation>Intensive Care National Audit and Research Centre, London, United Kingdom</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Intensive Care National Audit and Research Centre, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Angus, Derek C" sort="Angus, Derek C" uniqKey="Angus D" first="Derek C" last="Angus">Derek C. Angus</name><affiliation wicri:level="3"><nlm:affiliation>University of Pittsburgh School of Medicine, Pittsburgh</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><wicri:orgArea>University of Pittsburgh School of Medicine</wicri:orgArea></affiliation></author><author><name sortKey="Bailey, Michael" sort="Bailey, Michael" uniqKey="Bailey M" first="Michael" last="Bailey">Michael Bailey</name><affiliation wicri:level="1"><nlm:affiliation>Monash University, Melbourne, VIC, Australia</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Monash University, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Barnato, Amber E" sort="Barnato, Amber E" uniqKey="Barnato A" first="Amber E" last="Barnato">Amber E. Barnato</name><affiliation wicri:level="3"><nlm:affiliation>University of Pittsburgh School of Medicine, Pittsburgh</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><wicri:orgArea>University of Pittsburgh School of Medicine</wicri:orgArea></affiliation></author><author><name sortKey="Bellomo, Rinaldo" sort="Bellomo, Rinaldo" uniqKey="Bellomo R" first="Rinaldo" last="Bellomo">Rinaldo Bellomo</name><affiliation wicri:level="1"><nlm:affiliation>Monash University, Melbourne, VIC, Australia</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Monash University, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Canter, Ruth R" sort="Canter, Ruth R" uniqKey="Canter R" first="Ruth R" last="Canter">Ruth R. Canter</name><affiliation wicri:level="3"><nlm:affiliation>Intensive Care National Audit and Research Centre, London, United Kingdom</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Intensive Care National Audit and Research Centre, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Coats, Timothy J" sort="Coats, Timothy J" uniqKey="Coats T" first="Timothy J" last="Coats">Timothy J. Coats</name><affiliation wicri:level="1"><nlm:affiliation>University of Leicester, Leicester, United Kingdom</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Leicester, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Delaney, Anthony" sort="Delaney, Anthony" uniqKey="Delaney A" first="Anthony" last="Delaney">Anthony Delaney</name><affiliation wicri:level="4"><nlm:affiliation>University of Sydney, Sydney, Australia</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Gimbel, Elizabeth" sort="Gimbel, Elizabeth" uniqKey="Gimbel E" first="Elizabeth" last="Gimbel">Elizabeth Gimbel</name><affiliation wicri:level="3"><nlm:affiliation>University of Pittsburgh School of Medicine, Pittsburgh</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><wicri:orgArea>University of Pittsburgh School of Medicine</wicri:orgArea></affiliation></author><author><name sortKey="Grieve, Richard D" sort="Grieve, Richard D" uniqKey="Grieve R" first="Richard D" last="Grieve">Richard D. Grieve</name><affiliation wicri:level="3"><nlm:affiliation>London School of Hygiene and Tropical Medicine, London, United Kingdom</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Harrison, David A" sort="Harrison, David A" uniqKey="Harrison D" first="David A" last="Harrison">David A. Harrison</name><affiliation wicri:level="3"><nlm:affiliation>Intensive Care National Audit and Research Centre, London, United Kingdom</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Intensive Care National Audit and Research Centre, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Higgins, Alisa M" sort="Higgins, Alisa M" uniqKey="Higgins A" first="Alisa M" last="Higgins">Alisa M. Higgins</name><affiliation wicri:level="1"><nlm:affiliation>Monash University, Melbourne, VIC, Australia</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Monash University, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Howe, Belinda" sort="Howe, Belinda" uniqKey="Howe B" first="Belinda" last="Howe">Belinda Howe</name><affiliation wicri:level="1"><nlm:affiliation>Monash University, Melbourne, VIC, Australia</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Monash University, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Huang, David T" sort="Huang, David T" uniqKey="Huang D" first="David T" last="Huang">David T. Huang</name><affiliation wicri:level="3"><nlm:affiliation>University of Pittsburgh School of Medicine, Pittsburgh</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><wicri:orgArea>University of Pittsburgh School of Medicine</wicri:orgArea></affiliation></author><author><name sortKey="Kellum, John A" sort="Kellum, John A" uniqKey="Kellum J" first="John A" last="Kellum">John A. Kellum</name><affiliation wicri:level="3"><nlm:affiliation>University of Pittsburgh School of Medicine, Pittsburgh</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><wicri:orgArea>University of Pittsburgh School of Medicine</wicri:orgArea></affiliation></author><author><name sortKey="Mouncey, Paul R" sort="Mouncey, Paul R" uniqKey="Mouncey P" first="Paul R" last="Mouncey">Paul R. Mouncey</name><affiliation wicri:level="3"><nlm:affiliation>Intensive Care National Audit and Research Centre, London, United Kingdom</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Intensive Care National Audit and Research Centre, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Music, Edvin" sort="Music, Edvin" uniqKey="Music E" first="Edvin" last="Music">Edvin Music</name><affiliation wicri:level="3"><nlm:affiliation>University of Pittsburgh School of Medicine, Pittsburgh</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><wicri:orgArea>University of Pittsburgh School of Medicine</wicri:orgArea></affiliation></author><author><name sortKey="Peake, Sandra L" sort="Peake, Sandra L" uniqKey="Peake S" first="Sandra L" last="Peake">Sandra L. Peake</name><affiliation wicri:level="1"><nlm:affiliation>Monash University, Melbourne, VIC, Australia</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Monash University, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>University of Adelaide, Adelaide, SA, Australia</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Adelaide, Adelaide, SA</wicri:regionArea><wicri:noRegion>SA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Queen Elizabeth Hospital, Adelaide, SA, Australia</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Queen Elizabeth Hospital, Adelaide, SA</wicri:regionArea><wicri:noRegion>SA</wicri:noRegion></affiliation></author><author><name sortKey="Pike, Francis" sort="Pike, Francis" uniqKey="Pike F" first="Francis" last="Pike">Francis Pike</name><affiliation><nlm:affiliation>Eli Lilly, Indianapolis</nlm:affiliation><wicri:noCountry>no dot</wicri:noCountry></affiliation></author><author><name sortKey="Reade, Michael C" sort="Reade, Michael C" uniqKey="Reade M" first="Michael C" last="Reade">Michael C. Reade</name><affiliation wicri:level="1"><nlm:affiliation>University of Queensland, Brisbane, Australia</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Sadique, M Zia" sort="Sadique, M Zia" uniqKey="Sadique M" first="M Zia" last="Sadique">M Zia Sadique</name><affiliation wicri:level="3"><nlm:affiliation>London School of Hygiene and Tropical Medicine, London, United Kingdom</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Singer, Mervyn" sort="Singer, Mervyn" uniqKey="Singer M" first="Mervyn" last="Singer">Mervyn Singer</name><affiliation wicri:level="4"><nlm:affiliation>University College London, London, United Kingdom</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Yealy, Donald M" sort="Yealy, Donald M" uniqKey="Yealy D" first="Donald M" last="Yealy">Donald M. Yealy</name><affiliation wicri:level="3"><nlm:affiliation>University of Pittsburgh School of Medicine, Pittsburgh</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><wicri:orgArea>University of Pittsburgh School of Medicine</wicri:orgArea></affiliation></author></analytic><series><title level="j">The New England journal of medicine</title><idno type="eISSN">1533-4406</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Cardiotonic Agents (therapeutic use)</term><term>Combined Modality Therapy (MeSH)</term><term>Cost-Benefit Analysis (MeSH)</term><term>Erythrocyte Transfusion (MeSH)</term><term>Female (MeSH)</term><term>Fluid Therapy (MeSH)</term><term>Hospital Mortality (MeSH)</term><term>Hospitalization (economics)</term><term>Humans (MeSH)</term><term>Infusions, Intravenous (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Practice Guidelines as Topic (MeSH)</term><term>Quality-Adjusted Life Years (MeSH)</term><term>Randomized Controlled Trials as Topic (MeSH)</term><term>Resuscitation (economics)</term><term>Resuscitation (methods)</term><term>Shock, Septic (mortality)</term><term>Shock, Septic (therapy)</term><term>Survival Analysis (MeSH)</term><term>Treatment Outcome (MeSH)</term><term>Vasoconstrictor Agents (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term><term>Analyse coût-bénéfice (MeSH)</term><term>Analyse de survie (MeSH)</term><term>Années de vie ajustées sur la qualité (MeSH)</term><term>Association thérapeutique (MeSH)</term><term>Cardiotoniques (usage thérapeutique)</term><term>Choc septique (mortalité)</term><term>Choc septique (thérapie)</term><term>Essais contrôlés randomisés comme sujet (MeSH)</term><term>Femelle (MeSH)</term><term>Guides de bonnes pratiques cliniques comme sujet (MeSH)</term><term>Hospitalisation (économie)</term><term>Humains (MeSH)</term><term>Mortalité hospitalière (MeSH)</term><term>Mâle (MeSH)</term><term>Perfusions veineuses (MeSH)</term><term>Réanimation (méthodes)</term><term>Réanimation (économie)</term><term>Résultat thérapeutique (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Traitement par apport liquidien (MeSH)</term><term>Transfusion d'érythrocytes (MeSH)</term><term>Vasoconstricteurs (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Cardiotonic Agents</term><term>Vasoconstrictor Agents</term></keywords><keywords scheme="MESH" qualifier="economics" xml:lang="en"><term>Hospitalization</term><term>Resuscitation</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Resuscitation</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Shock, Septic</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Choc septique</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Réanimation</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Shock, Septic</term></keywords><keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Choc septique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Cardiotoniques</term><term>Vasoconstricteurs</term></keywords><keywords scheme="MESH" qualifier="économie" xml:lang="fr"><term>Hospitalisation</term><term>Réanimation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Combined Modality Therapy</term><term>Cost-Benefit Analysis</term><term>Erythrocyte Transfusion</term><term>Female</term><term>Fluid Therapy</term><term>Hospital Mortality</term><term>Humans</term><term>Infusions, Intravenous</term><term>Male</term><term>Middle Aged</term><term>Practice Guidelines as Topic</term><term>Quality-Adjusted Life Years</term><term>Randomized Controlled Trials as Topic</term><term>Survival Analysis</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse coût-bénéfice</term><term>Analyse de survie</term><term>Années de vie ajustées sur la qualité</term><term>Association thérapeutique</term><term>Essais contrôlés randomisés comme sujet</term><term>Femelle</term><term>Guides de bonnes pratiques cliniques comme sujet</term><term>Humains</term><term>Mortalité hospitalière</term><term>Mâle</term><term>Perfusions veineuses</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Traitement par apport liquidien</term><term>Transfusion d'érythrocytes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>After a single-center trial and observational studies suggesting that early, goal-directed therapy (EGDT) reduced mortality from septic shock, three multicenter trials (ProCESS, ARISE, and ProMISe) showed no benefit. This meta-analysis of individual patient data from the three recent trials was designed prospectively to improve statistical power and explore heterogeneity of treatment effect of EGDT.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We harmonized entry criteria, intervention protocols, outcomes, resource-use measures, and data collection across the trials and specified all analyses before unblinding. After completion of the trials, we pooled data, excluding the protocol-based standard-therapy group from the ProCESS trial, and resolved residual differences. The primary outcome was 90-day mortality. Secondary outcomes included 1-year survival, organ support, and hospitalization costs. We tested for treatment-by-subgroup interactions for 16 patient characteristics and 6 care-delivery characteristics.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>We studied 3723 patients at 138 hospitals in seven countries. Mortality at 90 days was similar for EGDT (462 of 1852 patients [24.9%]) and usual care (475 of 1871 patients [25.4%]); the adjusted odds ratio was 0.97 (95% confidence interval, 0.82 to 1.14; P=0.68). EGDT was associated with greater mean (±SD) use of intensive care (5.3±7.1 vs. 4.9±7.0 days, P=0.04) and cardiovascular support (1.9±3.7 vs. 1.6±2.9 days, P=0.01) than was usual care; other outcomes did not differ significantly, although average costs were higher with EGDT. Subgroup analyses showed no benefit from EGDT for patients with worse shock (higher serum lactate level, combined hypotension and hyperlactatemia, or higher predicted risk of death) or for hospitals with a lower propensity to use vasopressors or fluids during usual resuscitation.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>In this meta-analysis of individual patient data, EGDT did not result in better outcomes than usual care and was associated with higher hospitalization costs across a broad range of patient and hospital characteristics. (Funded by the National Institute of General Medical Sciences and others; PRISM ClinicalTrials.gov number, NCT02030158 .).</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28320242</PMID><DateCompleted><Year>2017</Year><Month>06</Month><Day>20</Day></DateCompleted><DateRevised><Year>2021</Year><Month>01</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1533-4406</ISSN><JournalIssue CitedMedium="Internet"><Volume>376</Volume><Issue>23</Issue><PubDate><Year>2017</Year><Month>06</Month><Day>08</Day></PubDate></JournalIssue><Title>The New England journal of medicine</Title><ISOAbbreviation>N Engl J Med</ISOAbbreviation></Journal><ArticleTitle>Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis.</ArticleTitle><Pagination><MedlinePgn>2223-2234</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1056/NEJMoa1701380</ELocationID><Abstract><AbstractText Label="BACKGROUND">After a single-center trial and observational studies suggesting that early, goal-directed therapy (EGDT) reduced mortality from septic shock, three multicenter trials (ProCESS, ARISE, and ProMISe) showed no benefit. This meta-analysis of individual patient data from the three recent trials was designed prospectively to improve statistical power and explore heterogeneity of treatment effect of EGDT.</AbstractText><AbstractText Label="METHODS">We harmonized entry criteria, intervention protocols, outcomes, resource-use measures, and data collection across the trials and specified all analyses before unblinding. After completion of the trials, we pooled data, excluding the protocol-based standard-therapy group from the ProCESS trial, and resolved residual differences. The primary outcome was 90-day mortality. Secondary outcomes included 1-year survival, organ support, and hospitalization costs. We tested for treatment-by-subgroup interactions for 16 patient characteristics and 6 care-delivery characteristics.</AbstractText><AbstractText Label="RESULTS">We studied 3723 patients at 138 hospitals in seven countries. Mortality at 90 days was similar for EGDT (462 of 1852 patients [24.9%]) and usual care (475 of 1871 patients [25.4%]); the adjusted odds ratio was 0.97 (95% confidence interval, 0.82 to 1.14; P=0.68). EGDT was associated with greater mean (±SD) use of intensive care (5.3±7.1 vs. 4.9±7.0 days, P=0.04) and cardiovascular support (1.9±3.7 vs. 1.6±2.9 days, P=0.01) than was usual care; other outcomes did not differ significantly, although average costs were higher with EGDT. Subgroup analyses showed no benefit from EGDT for patients with worse shock (higher serum lactate level, combined hypotension and hyperlactatemia, or higher predicted risk of death) or for hospitals with a lower propensity to use vasopressors or fluids during usual resuscitation.</AbstractText><AbstractText Label="CONCLUSIONS">In this meta-analysis of individual patient data, EGDT did not result in better outcomes than usual care and was associated with higher hospitalization costs across a broad range of patient and hospital characteristics. (Funded by the National Institute of General Medical Sciences and others; PRISM ClinicalTrials.gov number, NCT02030158 .).</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><CollectiveName>PRISM Investigators</CollectiveName></Author><Author ValidYN="Y"><LastName>Rowan</LastName><ForeName>Kathryn M</ForeName><Initials>KM</Initials><AffiliationInfo><Affiliation>Intensive Care National Audit and Research Centre, London, United Kingdom</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Angus</LastName><ForeName>Derek C</ForeName><Initials>DC</Initials><AffiliationInfo><Affiliation>University of Pittsburgh School of Medicine, Pittsburgh</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bailey</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Monash University, Melbourne, VIC, Australia</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barnato</LastName><ForeName>Amber E</ForeName><Initials>AE</Initials><AffiliationInfo><Affiliation>University of Pittsburgh School of Medicine, Pittsburgh</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bellomo</LastName><ForeName>Rinaldo</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Monash University, Melbourne, VIC, Australia</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Canter</LastName><ForeName>Ruth R</ForeName><Initials>RR</Initials><AffiliationInfo><Affiliation>Intensive Care National Audit and Research Centre, London, United Kingdom</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coats</LastName><ForeName>Timothy J</ForeName><Initials>TJ</Initials><AffiliationInfo><Affiliation>University of Leicester, Leicester, United Kingdom</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Delaney</LastName><ForeName>Anthony</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>University of Sydney, Sydney, Australia</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gimbel</LastName><ForeName>Elizabeth</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>University of Pittsburgh School of Medicine, Pittsburgh</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grieve</LastName><ForeName>Richard D</ForeName><Initials>RD</Initials><AffiliationInfo><Affiliation>London School of Hygiene and Tropical Medicine, London, United Kingdom</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harrison</LastName><ForeName>David A</ForeName><Initials>DA</Initials><AffiliationInfo><Affiliation>Intensive Care National Audit and Research Centre, London, United Kingdom</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Higgins</LastName><ForeName>Alisa M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Monash University, Melbourne, VIC, Australia</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Howe</LastName><ForeName>Belinda</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Monash University, Melbourne, VIC, Australia</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>David T</ForeName><Initials>DT</Initials><AffiliationInfo><Affiliation>University of Pittsburgh School of Medicine, Pittsburgh</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kellum</LastName><ForeName>John A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>University of Pittsburgh School of Medicine, Pittsburgh</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mouncey</LastName><ForeName>Paul R</ForeName><Initials>PR</Initials><AffiliationInfo><Affiliation>Intensive Care National Audit and Research Centre, London, United Kingdom</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Music</LastName><ForeName>Edvin</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>University of Pittsburgh School of Medicine, Pittsburgh</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peake</LastName><ForeName>Sandra L</ForeName><Initials>SL</Initials><AffiliationInfo><Affiliation>Monash University, Melbourne, VIC, Australia</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Adelaide, Adelaide, SA, Australia</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Queen Elizabeth Hospital, Adelaide, SA, Australia</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pike</LastName><ForeName>Francis</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Eli Lilly, Indianapolis</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reade</LastName><ForeName>Michael C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>University of Queensland, Brisbane, Australia</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sadique</LastName><ForeName>M Zia</ForeName><Initials>MZ</Initials><AffiliationInfo><Affiliation>London School of Hygiene and Tropical Medicine, London, United Kingdom</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Singer</LastName><ForeName>Mervyn</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>University College London, London, United Kingdom</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yealy</LastName><ForeName>Donald M</ForeName><Initials>DM</Initials><AffiliationInfo><Affiliation>University of Pittsburgh School of Medicine, Pittsburgh</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT02030158</AccessionNumber><AccessionNumber>NCT02030158</AccessionNumber></AccessionNumberList></DataBank></DataBankList><GrantList CompleteYN="Y"><Grant><GrantID>07/37/47</GrantID><Acronym>DH_</Acronym><Agency>Department of Health</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>P50 GM076659</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D017418">Meta-Analysis</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>03</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>N Engl J Med</MedlineTA><NlmUniqueID>0255562</NlmUniqueID><ISSNLinking>0028-4793</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002316">Cardiotonic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014662">Vasoconstrictor Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Ann Intern Med. 2017 Jul 18;167(2):JC6</RefSource><PMID Version="1">28715828</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>N Engl J Med. 2017 Sep 7;377(10 ):995</RefSource><PMID Version="1">28877021</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>N Engl J Med. ;377(10 ):994</RefSource><PMID Version="1">28880501</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Evid Based Med. 2017 Dec;22(6):223</RefSource><PMID Version="1">29056602</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002316" MajorTopicYN="N">Cardiotonic Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003131" MajorTopicYN="N">Combined Modality Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003362" MajorTopicYN="N">Cost-Benefit Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017707" MajorTopicYN="Y">Erythrocyte Transfusion</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005440" MajorTopicYN="Y">Fluid Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017052" MajorTopicYN="N">Hospital Mortality</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName><QualifierName UI="Q000191" MajorTopicYN="N">economics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007262" MajorTopicYN="N">Infusions, Intravenous</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017410" MajorTopicYN="N">Practice Guidelines as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019057" MajorTopicYN="N">Quality-Adjusted Life Years</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016032" MajorTopicYN="N">Randomized Controlled Trials as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012151" MajorTopicYN="N">Resuscitation</DescriptorName><QualifierName UI="Q000191" MajorTopicYN="N">economics</QualifierName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012772" MajorTopicYN="N">Shock, Septic</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014662" MajorTopicYN="N">Vasoconstrictor Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading></MeshHeadingList><InvestigatorList><Investigator ValidYN="Y"><LastName>Eaton</LastName><ForeName>Tammy L</ForeName><Initials>TL</Initials></Investigator><Investigator ValidYN="Y"><LastName>Keener</LastName><ForeName>Christopher</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Landis</LastName><ForeName>Kyle</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Stapleton</LastName><ForeName>Diana K</ForeName><Initials>DK</Initials></Investigator><Investigator ValidYN="Y"><LastName>Weissfeld</LastName><ForeName>Lisa A</ForeName><Initials>LA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Willochell</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wofford</LastName><ForeName>Kourtney A</ForeName><Initials>KA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kulstad</LastName><ForeName>Erik</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Watts</LastName><ForeName>Hannah</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Venkat</LastName><ForeName>Arvind</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hou</LastName><ForeName>Peter C</ForeName><Initials>PC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Massaro</LastName><ForeName>Anthony</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Parmar</LastName><ForeName>Siddharth</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Limkakeng</LastName><ForeName>Alexander T</ForeName><Initials>AT</Initials><Suffix>Jr</Suffix></Investigator><Investigator ValidYN="Y"><LastName>Brewer</LastName><ForeName>Kori</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Delbridge</LastName><ForeName>Theodore R</ForeName><Initials>TR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mainhart</LastName><ForeName>Allison</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Chawla</LastName><ForeName>Lakhmir S</ForeName><Initials>LS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Miner</LastName><ForeName>James R</ForeName><Initials>JR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Allen</LastName><ForeName>Todd L</ForeName><Initials>TL</Initials></Investigator><Investigator ValidYN="Y"><LastName>Grissom</LastName><ForeName>Colin K</ForeName><Initials>CK</Initials></Investigator><Investigator ValidYN="Y"><LastName>Swadron</LastName><ForeName>Stuart</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Conrad</LastName><ForeName>Steven A</ForeName><Initials>SA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Carlson</LastName><ForeName>Richard</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>LoVecchio</LastName><ForeName>Frank</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bajwa</LastName><ForeName>Ednan K</ForeName><Initials>EK</Initials></Investigator><Investigator ValidYN="Y"><LastName>Filbin</LastName><ForeName>Michael R</ForeName><Initials>MR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Parry</LastName><ForeName>Blair A</ForeName><Initials>BA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ellender</LastName><ForeName>Timothy J</ForeName><Initials>TJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sama</LastName><ForeName>Andrew E</ForeName><Initials>AE</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fine</LastName><ForeName>Jonathan</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nafeei</LastName><ForeName>Soheil</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Terndrup</LastName><ForeName>Thomas</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wojnar</LastName><ForeName>Margaret</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pearl</LastName><ForeName>Ronald G</ForeName><Initials>RG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wilber</LastName><ForeName>Scott T</ForeName><Initials>ST</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sinert</LastName><ForeName>Richard</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Orban</LastName><ForeName>David J</ForeName><Initials>DJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wilson</LastName><ForeName>Jason W</ForeName><Initials>JW</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ufberg</LastName><ForeName>Jacob W</ForeName><Initials>JW</Initials></Investigator><Investigator ValidYN="Y"><LastName>Albertson</LastName><ForeName>Timothy</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Panacek</LastName><ForeName>Edward A</ForeName><Initials>EA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Parekh</LastName><ForeName>Sohan</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gunn</LastName><ForeName>Scott R</ForeName><Initials>SR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rittenberger</LastName><ForeName>Jon S</ForeName><Initials>JS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wadas</LastName><ForeName>Richard J</ForeName><Initials>RJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Edwards</LastName><ForeName>Andrew R</ForeName><Initials>AR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kelly</LastName><ForeName>Matthew</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wang</LastName><ForeName>Henry E</ForeName><Initials>HE</Initials></Investigator><Investigator ValidYN="Y"><LastName>Holmes</LastName><ForeName>Talmage M</ForeName><Initials>TM</Initials></Investigator><Investigator ValidYN="Y"><LastName>McCurdy</LastName><ForeName>Michael T</ForeName><Initials>MT</Initials></Investigator><Investigator ValidYN="Y"><LastName>Weinert</LastName><ForeName>Craig</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Harris</LastName><ForeName>Estelle S</ForeName><Initials>ES</Initials></Investigator><Investigator ValidYN="Y"><LastName>Self</LastName><ForeName>Wesley H</ForeName><Initials>WH</Initials></Investigator><Investigator ValidYN="Y"><LastName>Dubinski</LastName><ForeName>Diane</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Phillips</LastName><ForeName>Carolyn A</ForeName><Initials>CA</Initials></Investigator><Investigator 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ValidYN="Y"><LastName>Graham</LastName><ForeName>C</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jacobs</LastName><ForeName>I</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Johanson</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jones</LastName><ForeName>P</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kruger</LastName><ForeName>P</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>McArthur</LastName><ForeName>C</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Myburgh</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nichol</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pettilä</LastName><ForeName>V</ForeName><Initials>V</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rajbhandari</LastName><ForeName>D</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Williams</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Williams</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bives</LastName><ForeName>G</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jovanovska</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lam</LastName><ForeName>L</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Little</LastName><ForeName>L</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Newby</LastName><ForeName>L</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bennett</LastName><ForeName>V</ForeName><Initials>V</Initials></Investigator><Investigator ValidYN="Y"><LastName>Board</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>McCracken</LastName><ForeName>P</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>McGloughlin</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nanjayya</LastName><ForeName>V</ForeName><Initials>V</Initials></Investigator><Investigator ValidYN="Y"><LastName>Teo</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hill</LastName><ForeName>E</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>O’Brien</LastName><ForeName>E</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sawtell</LastName><ForeName>F</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Schimanski</LastName><ForeName>K</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wilson</LastName><ForeName>D</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bolch</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Eastwood</LastName><ForeName>G</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kerr</LastName><ForeName>F</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Peak</LastName><ForeName>L</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Young</LastName><ForeName>H</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Edington</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fletcher</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Smith</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ghelani</LastName><ForeName>D</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nand</LastName><ForeName>K</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sara</LastName><ForeName>T</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Flemming</LastName><ForeName>D</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Grummisch</LastName><ForeName>M</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Purdue</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fulton</LastName><ForeName>E</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Grove</LastName><ForeName>K</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Harney</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Milburn</LastName><ForeName>K</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Millar</LastName><ForeName>R</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mitchell</LastName><ForeName>I</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rodgers</LastName><ForeName>H</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Scanlon</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Coles</LastName><ForeName>T</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Connor</LastName><ForeName>H</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Dennett</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Van Berkel</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Barrington</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Henderson</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mehrtens</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Dryburgh</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tankel</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Braitberg</LastName><ForeName>G</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>O’Bree</LastName><ForeName>B</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Shepherd</LastName><ForeName>K</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vij</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Allsop</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Haji</LastName><ForeName>D</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Haji</LastName><ForeName>K</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vuat</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bone</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Elderkin</LastName><ForeName>T</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Orford</LastName><ForeName>N</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ragg</LastName><ForeName>M</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kelly</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Stewart</LastName><ForeName>D</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Woodward</LastName><ForeName>N</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Harjola</LastName><ForeName>V P</ForeName><Initials>VP</Initials></Investigator><Investigator ValidYN="Y"><LastName>Okkonen</LastName><ForeName>M</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sutinen</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wilkman</LastName><ForeName>E</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fratzia</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Halkhoree</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Treloar</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ryan</LastName><ForeName>K</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sandford</LastName><ForeName>T</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Walsham</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jenkins</LastName><ForeName>C</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Williamson</LastName><ForeName>D</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Burrows</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hawkins</LastName><ForeName>D</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tang</LastName><ForeName>C</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Dimakis</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Micallef</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Parr</LastName><ForeName>M</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>White</LastName><ForeName>H</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Morrison</LastName><ForeName>L</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sosnowski</LastName><ForeName>K</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ramadoss</LastName><ForeName>R</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Soar</LastName><ForeName>N</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wood</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Franks</LastName><ForeName>M</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hogan</LastName><ForeName>C</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Song</LastName><ForeName>R</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tilsley</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rainsford</LastName><ForeName>D</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wells</LastName><ForeName>R</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Dowling</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Galt</LastName><ForeName>P</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lamac</LastName><ForeName>T</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lightfoot</LastName><ForeName>D</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Walker</LastName><ForeName>C</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Braid</LastName><ForeName>K</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>DeVillecourt</LastName><ForeName>T</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tan</LastName><ForeName>H S</ForeName><Initials>HS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Seppelt</LastName><ForeName>I</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Chang</LastName><ForeName>L F</ForeName><Initials>LF</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cheung</LastName><ForeName>W S</ForeName><Initials>WS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fok</LastName><ForeName>S K</ForeName><Initials>SK</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lam</LastName><ForeName>P K</ForeName><Initials>PK</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lam</LastName><ForeName>S M</ForeName><Initials>SM</Initials></Investigator><Investigator ValidYN="Y"><LastName>So</LastName><ForeName>H M</ForeName><Initials>HM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Yan</LastName><ForeName>W W</ForeName><Initials>WW</Initials></Investigator><Investigator ValidYN="Y"><LastName>Altea</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lancashire</LastName><ForeName>B</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gomersall</LastName><ForeName>C D</ForeName><Initials>CD</Initials></Investigator><Investigator ValidYN="Y"><LastName>Graham</LastName><ForeName>C A</ForeName><Initials>CA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Leung</LastName><ForeName>P</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Arora</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bass</LastName><ForeName>F</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Shehabi</LastName><ForeName>Y</ForeName><Initials>Y</Initials></Investigator><Investigator ValidYN="Y"><LastName>Isoardi</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Isoardi</LastName><ForeName>K</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Powrie</LastName><ForeName>D</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lawrence</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ankor</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Chester</LastName><ForeName>L</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Davies</LastName><ForeName>M</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>O’Connor</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Poole</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Soulsby</LastName><ForeName>T</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sundararajan</LastName><ForeName>K</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Greenslade</LastName><ForeName>J H</ForeName><Initials>JH</Initials></Investigator><Investigator ValidYN="Y"><LastName>MacIsaac</LastName><ForeName>C</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gorman</LastName><ForeName>K</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jordan</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Moore</LastName><ForeName>L</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ankers</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bird</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fogg</LastName><ForeName>T</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hickson</LastName><ForeName>E</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jewell</LastName><ForeName>T</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kyneur</LastName><ForeName>K</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>O’Connor</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Townsend</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Yarad</LastName><ForeName>E</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Brown</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Chamberlain</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cooper</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jenkinson</LastName><ForeName>E</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>McDonald</LastName><ForeName>E</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Webb</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Buhr</LastName><ForeName>H</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Coakley</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cowell</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator 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ValidYN="Y"><LastName>Santamaria</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Winter</LastName><ForeName>C</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Finckh</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Knowles</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>McCabe</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nair</LastName><ForeName>P</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Reynolds</LastName><ForeName>C</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ahmed</LastName><ForeName>B</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Barton</LastName><ForeName>D</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Meaney</LastName><ForeName>E</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Harris</LastName><ForeName>R</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Shields</LastName><ForeName>L</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Thomas</LastName><ForeName>K</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Karlsson</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kuitunen</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kukkurainen</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tenhunen</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Varila</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ryan</LastName><ForeName>N</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Trethewy</LastName><ForeName>C</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Crosdale</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Smith</LastName><ForeName>J C</ForeName><Initials>JC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vellaichamy</LastName><ForeName>M</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Furyk</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gordon</LastName><ForeName>G</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jones</LastName><ForeName>L</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Senthuran</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bates</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Butler</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>French</LastName><ForeName>C</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tippett</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kelly</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kwans</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Murphy</LastName><ForeName>M</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>O’Flynn</LastName><ForeName>D</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kurenda</LastName><ForeName>C</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Otto</LastName><ForeName>T</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Raniga</LastName><ForeName>V</ForeName><Initials>V</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ho</LastName><ForeName>H F</ForeName><Initials>HF</Initials></Investigator><Investigator ValidYN="Y"><LastName>Leung</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wu</LastName><ForeName>H</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bell</LastName><ForeName>Derek</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bion</LastName><ForeName>Julian</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hodgetts</LastName><ForeName>Timothy</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Young</LastName><ForeName>Duncan</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Harvey</LastName><ForeName>Sheila</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jahan</LastName><ForeName>Rahi</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Osborn</LastName><ForeName>Tiffany</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Power</LastName><ForeName>Sarah</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tan</LastName><ForeName>Jermaine</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Corlett</LastName><ForeName>Sarah</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Muskett</LastName><ForeName>Hannah</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Scott</LastName><ForeName>Rachael</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ahmed</LastName><ForeName>Vazeer</ForeName><Initials>V</Initials></Investigator><Investigator ValidYN="Y"><LastName>Boyle</LastName><ForeName>Adrian</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Scott-Donkin</LastName><ForeName>Andy</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Black</LastName><ForeName>Heather</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Smalley</LastName><ForeName>Christopher</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jacob</LastName><ForeName>Reni</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wooten</LastName><ForeName>Andrea</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Humphrey</LastName><ForeName>Julian</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pearson</LastName><ForeName>Sally Anne</ForeName><Initials>SA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Griffiths</LastName><ForeName>James</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Subramanyam</LastName><ForeName>Devasena</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Niblett</LastName><ForeName>David</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Krishnanankutty</LastName><ForeName>Sunil</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gao-Smith</LastName><ForeName>Fang</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Melody</LastName><ForeName>Teresa</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Couper</LastName><ForeName>Keith</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nichani</LastName><ForeName>Raj</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Brennan</LastName><ForeName>Emma</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tucker</LastName><ForeName>Simon</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Benger</LastName><ForeName>Jonathan</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Edwards</LastName><ForeName>Judith</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pollock</LastName><ForeName>Kathryn</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Arawwawala</LastName><ForeName>Dilshan</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hieatt</LastName><ForeName>Alex</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>McNeela</LastName><ForeName>Fiona</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Weldring</LastName><ForeName>Theresa</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Carungcong</LastName><ForeName>Jaime</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>MacNaughton</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>McMillan</LastName><ForeName>Helen</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tantam</LastName><ForeName>Kate</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Doyle</LastName><ForeName>Tony</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Moreton</LastName><ForeName>Sarah</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jones</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kendall</LastName><ForeName>Jason</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Worner</LastName><ForeName>Ruth</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gilbertson</LastName><ForeName>Anna</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Borland</LastName><ForeName>Colin</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Boys</LastName><ForeName>Suzanne</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ranjan</LastName><ForeName>Shashank</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Smith</LastName><ForeName>Ian</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Smith</LastName><ForeName>Neil</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mendham</LastName><ForeName>Victoria</ForeName><Initials>V</Initials></Investigator><Investigator ValidYN="Y"><LastName>Smith</LastName><ForeName>Paul</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Farras-Araya</LastName><ForeName>Roser</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vallance</LastName><ForeName>David</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Watt</LastName><ForeName>Phil</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Raymode</LastName><ForeName>Parizade</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hollos</LastName><ForeName>Laszlo</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hopkins</LastName><ForeName>Phil</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Riozzi</LastName><ForeName>Paul</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Couper</LastName><ForeName>Harriet</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Helyar</LastName><ForeName>Sinead</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Thompson</LastName><ForeName>Jonathan</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hales</LastName><ForeName>Dawn</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Essat</LastName><ForeName>Zubeir</ForeName><Initials>Z</Initials></Investigator><Investigator ValidYN="Y"><LastName>Andreou</LastName><ForeName>Prem</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gilby</LastName><ForeName>Susan</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Chilton</LastName><ForeName>Phil</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Miller</LastName><ForeName>Richard</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Butler</LastName><ForeName>John</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jefferies</LastName><ForeName>Alison</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Clark</LastName><ForeName>Richard</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sanders</LastName><ForeName>Graeme</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pinto</LastName><ForeName>Nuno</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Plowright</LastName><ForeName>Catherine</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Innes</LastName><ForeName>Richard</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bayford</LastName><ForeName>Dawn</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Richards</LastName><ForeName>Pippa</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gopal</LastName><ForeName>Shameer</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pooni</LastName><ForeName>Jagtar Singh</ForeName><Initials>JS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Spencer</LastName><ForeName>Hazel</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Napier</LastName><ForeName>James</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Warrington</LastName><ForeName>Ena</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kevern</LastName><ForeName>Liam</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hunt</LastName><ForeName>Jane</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Barrett</LastName><ForeName>Colin</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sykes</LastName><ForeName>Eliot</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Connelly</LastName><ForeName>Karen</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Yates</LastName><ForeName>Bryan</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Carle</LastName><ForeName>Coralie</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Croft</LastName><ForeName>Theresa</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jenkins</LastName><ForeName>Nick</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Reschreiter</LastName><ForeName>Henrik</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Camsooksai</LastName><ForeName>Julie</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Barcraft-Barnes</LastName><ForeName>Helena</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Snelson</LastName><ForeName>Catherine</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bergin</LastName><ForeName>Colin</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Keats</LastName><ForeName>Frank</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Linnett</LastName><ForeName>Vanessa</ForeName><Initials>V</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ritzema</LastName><ForeName>Jenny</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Christian</LastName><ForeName>Steve</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Harvey</LastName><ForeName>Daniel</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Miller</LastName><ForeName>Philip</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Woodford</LastName><ForeName>Claudia</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bolland</LastName><ForeName>Anna</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Keating</LastName><ForeName>Liza</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mossop</LastName><ForeName>David</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jones</LastName><ForeName>Carys</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Martin</LastName><ForeName>David</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Willett</LastName><ForeName>Emma</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Swallow</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>McBride</LastName><ForeName>Sam</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ijaz</LastName><ForeName>Asim</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Datta</LastName><ForeName>Jay</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Craig</LastName><ForeName>Jayne</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Owen</LastName><ForeName>Thomas</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Williams</LastName><ForeName>Alex</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>McMullan</LastName><ForeName>Sean</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Baldwin</LastName><ForeName>Jackie</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Zuleika</LastName><ForeName>Mehrun</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Carvalho</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Agranoff</LastName><ForeName>Dan</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ingoldby</LastName><ForeName>Fiona</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ortiz-Ruiz De Gordoa</LastName><ForeName>Laura</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ridley</LastName><ForeName>Carrie</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Clement</LastName><ForeName>Ian</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Higham</LastName><ForeName>Charley</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Martin</LastName><ForeName>Bruce</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Clayton</LastName><ForeName>Kate</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Chadwick</LastName><ForeName>Julie</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Frey</LastName><ForeName>Christian</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Miller</LastName><ForeName>Diane</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Laverick</LastName><ForeName>Philippa</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Iftikhar</LastName><ForeName>Khurram</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Higgins</LastName><ForeName>David</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Katsande</LastName><ForeName>Victoria</ForeName><Initials>V</Initials></Investigator><Investigator ValidYN="Y"><LastName>Chikungwa</LastName><ForeName>Moses</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jackson</LastName><ForeName>Clare</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Watters</LastName><ForeName>Malcolm</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Liddiard</LastName><ForeName>Paul</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gannon</LastName><ForeName>Kate</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Howard-Griffin</LastName><ForeName>Richard</ForeName><Initials>R</Initials></Investigator><Investigator 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ValidYN="Y"><LastName>Hartley</LastName><ForeName>Stephen</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Crossingham</LastName><ForeName>Iain</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hinchcliffe</LastName><ForeName>Joanne</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Phoenix</LastName><ForeName>Leanne</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Harris</LastName><ForeName>Tim</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pott</LastName><ForeName>Jason</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bellhouse</LastName><ForeName>Geoffrey</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mercer</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Investigator><Investigator 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